Genetic mismatch explains sizable variation of COVID-19 vaccine efficacy in clinical trials (preprint)

Pulling vaccine efficacy and effectiveness (VE) outcomes from 17 reports of 9 different vaccine products and through sequence analysis, we found that genetic mismatch explained sizable variations in VE. The findings suggested the potential need of timely optimizing vaccine antigens as new dominant viral strains emerge.

Monitoring Disease Transmissibility of 2019 Novel Coronavirus Disease in Zhejiang, China (preprint)

We monitored the transmissibility of 2019 novel coronavirus disease in Zhejiang accounting the transmissions from imported cases. Even though Zhejiang is one of the worst-affected provinces, an interruption of disease transmission (i.e. instantaneous reproduction numbers <1) was observed in early/mid-February after an early social-distancing response to the outbreak.